IgG1 allows ELOCTATE to extend its half-life by binding to the neonatal Fc receptor1
IgG1 is a naturally occurring protein that has anti-inflammatory and immunomodulatory properties1-3
The molecular mechanism behind the effects achieved by ELOCTATE
yet fully understood, including the interaction with cellular Fc receptors that
ELOCTATE may interact with3
Fc=fragment crystallizable; FVIII=factor VIII; IgG1=immunoglobulin G; MOE=mechanism of extension.